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Value of routine radiotherapy confirmed in ductal carcinoma.(Gynecology)

OB GYN News

| February 15, 2006 | Jancin, Bruce | COPYRIGHT 2006 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN ANTONIO -- Radiotherapy as part of breast-conserving treatment for patients with ductal carcinoma in situ reduced the 10-year risk of local recurrence by 47% in a large European randomized trial, Dr. Nina Bijker reported at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.

For this reason, whole-breast radiation therapy remains the standard of care in women with ductal carcinoma in situ (DCIS), despite its problematic side effects and inconvenience, added Dr. Bijker of the Netherlands Cancer Institute, Amsterdam.

The sole patient subgroup in the European Organization for Research and Treatment of Cancer (EORTC) trial 10853 who were found to have a low risk of recurrence without radiotherapy was a small one: women over age 40 years with well-differentiated micropapillary or clinging-type DCIS lesions.

"In those lesions you could consider omitting radiotherapy. But that was the only group of patients that had a much lower risk of local recurrence. The cribriform lesions did as badly as the solid or comedo lesions," she added.

Dr. Bijker reported on 1,010 patients with DCIS who underwent local excision and randomization to no radiation or to 50 Gy of whole-breast radiotherapy delivered in 25 ...

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