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For women only: aspirin can reduce first stroke risk by 17%.(Clinical Rounds)
DALLAS -- Aspirin appears to be effective for primary prevention of stroke in women, but not in men, according to the findings of a metaanalysis that was presented by Dr. David L. Brown at the annual scientific sessions of the American Heart Association.
"For women with no history of cardiovascular disease, aspirin reduces the risk of total stroke by reducing the risk of ischemic stroke," said Dr. Brown, who is professor of medicine at the State University of New York at Stony Brook.
"Among men, aspirin slightly increases the total risk of stroke because it has no effect in reducing ischemic strokes and actually increases the risk of hemorrhagic stroke," he explained.
The role of aspirin as an effective, safe, and inexpensive agent for secondary prevention of stroke in patients with known cardiovascular disease has been firmly established.
However, the same cannot be said with regard to the use of aspirin for primary prevention of stroke, which remains an unresolved issue.
To shed new light on the subject, Dr. Brown performed a metaanalysis of six randomized controlled primary prevention trials.
Three included only men, the largest being the 22,071-subject Physicians' Health Study.
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