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Urine test for breast cancer risk shows promise: for high-risk women, early signs of change in status could be detected between scheduled mammograms.(Gynecology)
SAN ANTONIO -- A simple urine test for selected matrix metalloproteinases may provide a novel noninvasive means of assessing a woman's risk of developing breast cancer, Dr. Susan E. Pories reported at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.
Urinary levels of two biomarkers--matrix metalloproteinase-9 (MMP-9) and a disintegrin and metalloprotease 12 (ADAM12)--appear to be independent predictors of the presence of breast atypical hyperplasia or lobular carcinoma in situ (LCIS), both of which are well established predictors of increased risk of breast cancer, explained Dr. Pories of Beth Israel Deaconess Medical Center, Boston.
Dr. Pories and her coworkers had previously found that levels of MMP-9 and ADAM12 increase with more advanced disease status in patients who have breast cancer.
In the current study, she reported on urine samples obtained from 44 women with atypical ductal or atypical lobular hyperplasia, 24 with lobular carcinoma in situ, and 80 healthy controls.
For a 30-mL urine sample testing positive for both MMP-9 and ADAM12, the probability that the sample belonged to a woman with LCIS or atypical hyperplasia was 100%.
A urine sample that was MMP-9 negative but ADAM12 positive, had a 67% ...
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A urine test for two biomarkers, matrix metalloproteinase-9 (MMP-9...carcinoma in situ (LCIS), both of which are predictors of breast cancer risk. At a breast cancer symposium in San Antonio, Dr. Susan Pories reported on urine...
- Urine test promising for assessing breast cancer risk.(Women's Health)
- Magazine article from: Internal Medicine News February 1, 2006 700+ words
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- Magazine article from: Family Practice News Jancin, Bruce February 1, 2006 700+ words
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- Urine Test Predicts Heart Problems In Postmenopausal Women.(albumin)
- Newspaper article from: Heart Disease Weekly July 15, 2001 700+ words
...studied were among 12,239 volunteers who donated a urine sample between 1976 and 1978 while participating in an experimental breast cancer screening study. When the women provided a sample - each of which was frozen and stored - they also granted permission for...
- Urine Test Predicts Heart Problems In Postmenopausal Women.(urinary albumin is...
- Magazine article from: Women's Health Weekly July 12, 2001 700+ words
...studied were among 12,239 volunteers who donated a urine sample between 1976 and 1978 while participating in an experimental breast cancer screening study. When the women provided a sample - each of which was frozen and stored - they also granted permission for...
