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One hundred eighty-four nonsmoking volunteers (mean age, 58 years) were randomly assigned to receive, in double-blind fashion, one of the following for two months: 1) vitamin C 500 (mg/day), 2) vitamin E (RRR-alpha-tocopheryl acetate, 400 IU/day), 3) both supplements, or 4) placebo. The mean fasting serum uric acid concentration decreased (-0.5 mg/dl) in the vitamin C groups and increased (+0.09 mg/dl) in the no-vitamin-C groups (p
Comment: Lowering serum uric acid levels is useful for the prevention and management of gout. As hyperuricemia is also an independent cardiovascular disease risk factor, reducing serum uric acid levels may be one of the many mechanisms whereby vitamin C enhances heart health. The results of the present study indicate that supplementation with 500 mg/day of vitamin C for two months produced a modest reduction in serum uric acid levels. Previous research suggested that this ...