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MONTREAL -- Continuous oral contraceptive regimens suppress ovulation better than do conventional 21-day regimens, according to research presented at the conjoint annual meeting of the American Society for Reproductive Medicine and the Canadian Fertility and Andrology Society.
This effect of continuous oral contraceptives (COCs) has not been previously reported, said Roger Pierson, Ph.D., explaining that COCs have been promoted primarily for their ability to eliminate cyclic bleeding and premenstrual symptoms.
"The side effect of not bleeding is much more effective contraceptive control," said Dr. Pierson, professor of obstetrics, gynecology, and reproductive sciences at the University of Saskatchewan, Saskatoon.
In his single-center, randomized, open-label trial sponsored by the Canadian Institutes of Health Research, Dr. Pierson compared two different formulations of traditional 21-day oral contraceptive (OC) regimens with the same formulations given continuously for 28 days per cycle. Women took the pills for three cycles. Transvaginal ultrasonography was used to monitor follicular development once weekly for the first 3 weeks of the study and then every third day until the end of the third cycle.
The nine women on the 28-day regimen of 30-mcg ethinyl estradiol/150-mcg ...