AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Widely Used Cardiac Surgery Drug Doubles Risk of Kidney Failure;Aprotinin Proven Unsafe 13 Years After Approval in Today's New England Journal of Medicine.
(From US Newswire)
To: Metro Desk, Health Reporter
Contact: Tyler Prell of The Hauser Group for IREF, 202-518-8047 (8 a.m. to 6 p.m. EST) or 202-210-1203 (all other times)
SAN BRUNO, Calif., Jan. 25 /U.S. Newswire/ -- Aprotinin -a a drug approved by the FDA, marketed internationally for the last 13 years, and given to an estimated one million surgery patients to limit bleeding -a has now been proven to double a patient's risk of kidney failure, and increase the risk of heart attack, heart failure, and stroke. These results -a published in this week's New England Journal of Medicine -a are based on an independent (non-commercial), observational study conducted by The Ischemia Research and Education Foundation (IREF), in association with the McSPI Research Group -- nonprofit biomedical research organizations dedicated to saving and extending lives.
"Our study provides compelling evidence of aprotinin's serious risks, and strongly suggests discontinuation of use and replacement with either of the two alternative generic and far less costly medications proven safe in this study," said IREF and McSPI founder and principal scientist, Dennis T. Mangano, Ph.D., M.D. "Certainly, our findings -a coming on the heels of the Vioxx experience -a indicate that the problem of drug safety is not only ubiquitous,…
- The use of aprotinin for patients undergoing coronary artery bypass graft...
- Magazine article from: AORN Journal Whitener, Regina T. Doyal, Virginia L. January 1, 1996 700+ words
...the use of a hemostatic agent (ie, aprotinin [Trasylol]) that reduces the need...that intraoperative administration of aprotinin can alleviate the need for blood transfusions...pathogens (eg, hepatitis, HIV). Aprotinin also offers a treatment option to patients...
- APROTININ (Intravenous route).(Drug overview)
- USP DI-Volume II, Advice for the Patient: Drug Information in Lay Language May 1, 2007 700+ words
Warning -- Aprotinin administration may cause fatal anaphylactic or anaphylactoid...anaphylactoid reactions is increased among patients with prior aprotinin exposure and a history of any prior aprotinin exposure must be sought prior to aprotinin administration...
- Aprotinin Can Reduce Blood Loss In Aspirin-Treated Patients.
- Newspaper article from: Heart Disease Weekly November 18, 2001 700+ words
...Michael Greer, senior medical writer - Aprotinin reduces postoperative blood loss in heart...unclear if "low-dose postoperative aprotinin has any beneficial effects in patients...patients were suitable candidates for aprotinin administration, even those who continued...
- Aprotinin can preserve myocardial function after ischemia-reperfusion injury.
- Newspaper article from: Heart Disease Weekly April 13, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Aprotinin can preserve myocardial function after...possible injury to other major organs. "Aprotinin, a nonspecific serine protease inhibitor...inflammatory variables. Data indicate that aprotinin may provide protection from ischemia...
- Fibrinolysis rises significantly during low-dose aprotinin treatment.
- Newspaper article from: Heart Disease Weekly May 11, 2003 700+ words
...in patients treated with low doses of aprotinin. According to a recent study from Germany, "low-dose aprotinin inhibits hyperfibrinolysis in cardiac...fibrinolysis may occur despite low dose-aprotinin administration." F. Kuepper and coauthors...
- Low-Dose Aprotinin Reduces Need During Aortic Surgery.(reduces need for...
- Newspaper article from: Heart Disease Weekly Henderson, CW February 11, 2001 700+ words
...Administration of the seine protease inhibitor aprotinin prior to surgery requiring circulatory...conducted a study to "compare the effects of aprotinin on blood product use and postoperative...thoracic aortic surgery" ("The effects of aprotinin on blood product transfusion associated...
- Aprotinin in major orthopedic operations significantly reduced blood loss.
- Newspaper article from: Medical Devices & Surgical Technology Week June 1, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Aprotinin in major orthopedic operations significantly...controlled study the effect of high-dose aprotinin on blood loss in patients admitted for...in the control group to 736 ml in the aprotinin group (p=.002). The mean requirement...
- Aprotinin reduces blood loss in spinal surgery for idiopathic scoliosis.
- Newspaper article from: Medical Devices & Surgical Technology Week October 26, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Aprotinin reduces blood loss in spinal surgery...Journal of Pediatric Orthopaedics, "Aprotinin is a proteinase inhibitor with antifibrinolytic...blood loss. To evaluate the effect of aprotinin in reducing blood loss during spinal...
- Utility of aprotinin in joint replacement reviewed.
- Newspaper article from: Health & Medicine Week August 30, 2004 700+ words
...com & NewsRx.net) -- The utility of aprotinin in joint replacement surgery has reviewed. "Aprotinin is a potent pharmacological agent that...transfusions has decreased with the use of aprotinin." "Recently, studies using aprotinin...
- Columbia Study Shows How Doctors May Be Able to Better Manage Blood Glucose...
- News wire article from: Ascribe Higher Education News Service October 24, 2005 700+ words
...completed the first human study to show that aprotinin, a protease inhibitor, was associated...showed that CABG patients receiving aprotinin had 24 percent lower blood glucose levels...resistance compared to patients not receiving aprotinin. The association of aprotinin with reduced...
Other Gale sites: Encyclopedia.com | HighBeam Research | Acquire Content | Books & Authors | Goliath | MovieRetriever | Smart QandA
The AccessMyLibrary advertising network includes:
