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VANCOUVER, B.C. -- Color change, in addition to color variegation, often heralds melanoma, thus bolstering the need for adding an E to the ABCD mnemonic for melanoma detection, Robert J. Friedman, M.D., said at the Sixth World Congress on Melanoma.
The color change appears to occur often before a melanoma exhibits a change in diameter, meaning it can signal a melanoma long before its diameter reaches 6 mm, said Dr. Friedman, an originator of the ABCD criteria.
Dr. Friedman said he followed 24 very small lesions (2.3-5.7 mm in diameter) that, when removed after a period of observation, were found to be melanomas.
In 17 of the 24 lesions, color was the first change noted, followed by a change in diameter, then the appearance of asymmetry.
Only two lesions were invasive; both had a diameter greater than 4 mm. This is consistent with ...
Source: HighBeam Research, Change in color can be earliest sign of melanoma.(Clinical Rounds)