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CHARLESTON, S. C. -- The development of chorioamnionitis in patients with preterm premature rupture of membranes is associated with an increased risk for adverse neonatal outcomes, Natali Aziz, M.D., reported at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology.
In a retrospective cohort study of 1,153 patients who gave birth between 1980 and 2001 with a diagnosis of preterm premature rupture of membranes (PPROM) made at 24 to 34 weeks' gestation, 29% were diagnosed with chorioamnionitis before delivery. Univariate outcomes on a variety of measures--such as Apgar scores and incidence of respiratory distress syndrome, intracerebral hemorrhage, and pneumonia--were significantly poorer in neonates born to mothers with chorioamnionitis, compared with those born to mothers without chorioamnionitis, said Dr. Aziz of the University of California, San Francisco.
"Management in this setting is better examined prospectively in a randomized, controlled trial, yet given these data, when managing a patient with preterm premature rupture of membranes we must weigh the risks of prematurity against those of expectant management with the ongoing possibility of development of chorioamnionitis," she said.
Differences were noted in the rates of chorioamnionitis based ...