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Nearly everyone has stubbed a toe or skinned a knee. The pain may be severe, but most of the time it is fleeting. In some people, however, the pain persists for months, even years, and becomes debilitating. On a balmy evening about a year ago, a woman I will call Barbara was strolling in Manhattan when her foot caught the curb as she crossed a street, and she fell face down on the pavement. A jogger helped her up, and she hobbled the few blocks to her apartment. Her left knee was bright red and extremely sore. Over the next few days, it turned black-and-blue, and the pain did not subside. Instead of the dull discomfort typical of a bruise, Barbara felt as though she had a ...