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Back pain is reduced for at least 30 months after stopping teriparatide.(Gynecology)
VIENNA -- The risk of developing new-onset back pain is markedly decreased during and for at least 30 months after stopping teriparatide (Forteo) for the treatment of osteoporosis, Jean-Yves Reginster, M.D., Ph.D., reported at the annual European congress of rheumatology.
He presented a metaanalysis of four Eli Lilly-sponsored randomized double-blind clinical trials involving 1,222 teriparatide-treated patients and 691 controls. The control groups in two of the trials received placebo. In the other two, controls got 10 mg/ day of alendronate or hormone therapy. The median follow-up after discontinuing teriparatide was more than 31 months.
The incidence of any new back pain during 4,157 patient-years at risk was 6.9 cases per 100 patient-years among subjects in the teriparatide-treated group, compared with 9.3 cases per 100 patient-years in controls. (See box.)
There was no significant difference in the incidence of new back pain in patients who received 20 mcg/day of subcutaneous teriparatide and in those who got 40 mcg/ day. Rates in teriparatide-treated patients and controls appeared to diverge after 6 months of therapy, noted Dr. Reginster, director and professor of epidemiology, public health, and health economics at the University of Liege, Belgium.
The relative risk of developing severe back pain during teriparatide therapy or for 30 months after treatment ended was reduced by 61%, compared with controls. The risk of developing moderate or severe back pain was reduced by 28%. And the risk of any new-onset back pain was 27% lower in the teriparatide group.
In a separate presentation, Thomas Nickelsen, M.D., said that postmenopausal osteoporotic women showed a significant decrease in self-as-sessed back pain after 1 and 6 months of teriparatide in the ongoing European Forteo Study (EUROFORS). At baseline, the women rated ...
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Source: HighBeam Research, Back pain is reduced for at least 30 months after stopping...