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Rapid test has its place in GBS infection prevention.(Obstetrics)
CHARLESTON, S.C. -- Rapid realtime polymerase chain reaction testing for group B streptococcus detection proved at least as sensitive and specific as standard culture screening at 35-37 weeks' gestation in a recent study.
Two vaginal-rectal swabs were collected from each of 190 women enrolled in the study after presenting in labor. One sample was tested using the Food and Drug Administration-approved IDI-Strep B assay and analyzed using the FDA-approved Smart Cycler I instrument; the other sample was used for enriched culture for GBS, Deborah M. Money, M.D., reported at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology.
In the more than 150 women in the study who also underwent the currently recommended 35- to 37-week culture screening and had results available for analysis, the rapid test had a sensitivity of 89%, compared with 85% for the 35- to 37-week culture, and a positive predictive value of 97%, compared with 94% for the 35- to 37-week culture. The values were based on comparison with culture at delivery, said Dr. Money of the University of British Columbia, Vancouver.
The median time from specimen acquisition to availability of results with the rapid test was 90 minutes, with a range of 30 minutes to 4 hours. About 87% of results were available within 2 hours; cultures can require a few days for results. Colonization rates were about 30% with both the rapid test and the culture, she said.
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Source: HighBeam Research, Rapid test has its place in GBS infection prevention.(Obstetrics)