Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) as recurrence of aborted PMR.(polymyalgia rheumatica )

A comparison of clinical and laboratory findings in patients with RS3PE alone, PMR alone, and RS3PE associated with PMR has been recently published by Cantini et al.[1] Their results suggest that the three conditions might represent a continuum, with PMR, a more severe condition, at one end and, RS3PE alone, at the other. PMR has a longer duration, is more commonly associated with systemic symptoms, requires higher doses of steroids for a longer time, and shows more relapses and recurrences. Although Cantini et al emphasised the similarities between PMR and RS3PE, they concluded that RS3PE alone is a separate entity. Other studies by the same group of authors have shown that RS3PE may be a feature of different diseases, such as spondyloarthropathies, psoriatic arthritis, rheumatoid arthritis …