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Bipolar disorder drugs.(DRUGS, PREGNANCY, AND LACTATION)
Two of the agents widely used to treat bipolar illness are established teratogens. Lithium is associated with a 0.05% risk of Ebstein's anomaly, a modest teratogenic effect. Sodium valproate is associated with a risk as high as 8% for major congenital malformations, most notably, neural tube defects and cardiac malformations, according to recent data from the North American Antiepileptic Drug (AED) Pregnancy Registry.
This increased risk for major organ malformations associated with first trimester exposure to these compounds raises concerns about the possible risk of longer term neurobehavioral sequelae associated with prenatal exposure.
Several studies published over the last few years have consistently shown an…
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Source: HighBeam Research, Bipolar disorder drugs.(DRUGS, PREGNANCY, AND LACTATION)
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