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UFE failure rate pegged at 10.7%.(News)
PHILADELPHIA -- Uterine fibroid embolization had a failure rate of 10.7% in the largest patient series to examine long-term failure rates associated with the procedure.
"Based on our findings, gynecologists should offer uterine fibroid embolization [UFE] as a nonsurgical treatment option for symptomatic fibroids and should inform patients of these long-term failure rates," said Jack Huang, M.D., a resident at McGill University in Montreal. Dr. Huang and Togas Tulandi, M.D., a professor at the university, were lead investigators in the study.
The only other study to look at long-term outcomes of UFE--a 3-year follow-up of 51 UFE patients and 30 myomectomy patients--found a much higher UFE failure rate of 29%, with a hysterectomy rate of 12% (Obstet. Gynecol. 2002;100:864-8), Dr. Huang said.
The current study was a retrospective chart review of 234 patients (mean age 45 years) who underwent UFE performed by a single interventional radiologist between 1997 and 2004.
The procedure was performed bilaterally, using 355- to 500-[micro]m polyvinyl alcohol particles. Over the course of the study period, the embolization evolved to a less aggressive end point--from complete stasis of uterine vessel flow to very sluggish forward flow on angiogram.
All patients underwent ultrasound before the procedure and at 3 and 6 months after the procedure. Long-term failure was defined as persistent symptoms requiring hysterectomy, myomectomy, or repeated UFE.
Surgical complications included one intraoperative ureteral injury and two postoperative complications, including one ileus and one case of pneumonia.
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Source: HighBeam Research, UFE failure rate pegged at 10.7%.(News)