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IMPORTANCE OF METAPLASTIC SUBTYPES AND SQUAMO-COLUMNAR CROSS-TALK IN THE AETIOPATHOGENESIS OF INFLAMMATORY AND MALIGNANT COMPLICATIONS IN BARRETT'S OESOPHAGUS (BE).(Abstract)
Dept of Gastroenterology, St Barts & the London Hospital, Turner Street, London, UK
We have previously demonstrated an inflammatory gradient in long segments of BE. Acute inflammation occurs proximally with oesophagitis at the neo squamo-columnar junction, whereas anti-inflammatory cytokines predominate distally. We investigated whether the proximal-distal differences occur due to the metaplastic subtypes or the interaction between the squamous and columnar cell types.
Methods: Mucin histochemical staining was performed to identify areas of gastric compared with specialized intestinal metaplasia (SIM types I, II, III), (multiple samples from n=35 patients) …
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- Inflammatory gradient in Barrett's oesophagus: implications for disease...
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Magazine article from: Gut
Fitzgerald, R.C. Abdalla, S. Onwuegbusi, B.A. Sirieix, P. Saeed, I.T. Burnham, W.R. Farthing, M.J.G.
September 1, 2002
700+ words
