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Dept of Gastroenterology, St Barts & the London Hospital, Turner Street, London, UK
We have previously demonstrated an inflammatory gradient in long segments of BE. Acute inflammation occurs proximally with oesophagitis at the neo squamo-columnar junction, whereas anti-inflammatory cytokines predominate distally. We investigated whether the proximal-distal differences occur due to the metaplastic subtypes or the interaction between the squamous and columnar cell types.
Methods: Mucin histochemical staining was performed to identify areas of gastric compared with specialized intestinal metaplasia (SIM types I, II, III), (multiple samples from n=35 patients) …