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HELICOBACTER PYLORI LEADS TO DECREASED SURFACE EXPRESSION OF [beta]-CATENIN IN EPITHELIAL CELLS.(Abstract)
J.R. Bebb [1]
L. Leach [2]
J.C. Atherton [1]
(1.) Division of Gastroenterology & Institute of Infections and Immunity and
(2.) School of Biomedical Sciences, University Hospital, Nottingham, UK
Background: H.pylori is implicated in the pathogenesis of gastric cancer. The cadherin-catenin complex (of which [beta]-catenin is a key signalling component) promotes stable adhesion of epithelial monolayers and is altered in several epithelial cancers, including gastric cancer. Furthermore, germline mutations in the E-cadherin gene have been described in familial gastric cancer.
Aim: To assess the effect of H. pylori on …
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