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United States of America -- The manufacturer of rivastigmine (Exelon[R]), indicated for Alzheimer disease has informed health professionals of recent changes to the prescribing information. These changes provide guidelines for reinitiating therapy in patients who have interrupted treatment with rivastigmine in order to reduce the risk of severe vomiting. (1)
There is limited experience related to restarting rivastigmine after an interruption in therapy at doses higher than the recommended starting dose. However, to reduce the possibility of severe vomiting in patients who have interrupted therapy for longer than several days, treatment should be reinitiated with the …