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Anti-cancer DNA vaccination is less effective in older mice than younger.(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- Study results showed that DNA vaccination to induce immunity against cancerous tumors was less effective in older mice than younger animals.
The researchers conducting the work suggest this would be the case in humans, as well.
M. Provinciali and colleagues at the INRCA Laboratory of Tumor Immunology in Italy "evaluated the effectiveness of vaccination with a HER-2/neu DNA plasmid to induce protective immunity against HER-2/neu overexpressing syngeneic TUBO tumor cells in old ages."
They vaccinated both young and old Balb/c mice three times with a pCMVneuNT DNA plasmid, then presented challenge with TUBO cells.
The researchers found that the vaccine completely protected the young mice, but the older mice exhibited less than 60% protection.
"Anti-p185(neu) antibodies were found in the sera from both young and old immunized mice, even if antibody production was significantly higher in young in comparison with old mice. Similarly, higher anti-p185(neu), lymphocyte proliferation ...
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Source: HighBeam Research, Anti-cancer DNA vaccination is less effective in older mice than...