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MF59C.1-adjuvanted recombinant vaccine reported safe, immunogenic.(human parvovirus B19 vaccine)(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- A recombinant human parvovirus B19 vaccine formulated with MF59C.1 adjuvant was found safe and immunogenic in a small, Phase I clinical trial.
Medimmune Inc. reported the safety and immunogenicity data from its randomized, double-blind, Phase I trial of its recombinant human parvovirus B19 vaccine (MEDI-491) composed of the VP1 and VP2 capsid proteins and formulated with MF59C.1 adjuvant.
"Parvovirus B19-seronegative adults (n=24) received either 2, 5, or 25 mcg MEDI-491 at 0, 1, and 6 months," said W.R. Ballou and colleagues at Medimmune.
They reported that "all volunteers developed neutralizing antibody titers that peaked after the third immunization and were sustained through study day 364."
Ballou and coauthors ...
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