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Recombinant SFV expressing fusion protein eliminated tumors in vaccinated mice.(Semliki Forest virus)(human papillomavirus infection vaccine)(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- Recombinant Semliki Forest virus expressing a fusion protein of human papillomavirus E6 and E7 eliminated tumors in immunized mice, virologists report.
According to researchers in the Netherlands, "Previously, we described the efficacy of immunization with recombinant Semliki Forest virus (SFV) expressing the human papillomavirus 16 (HPV) oncoproteins E6 and E7 in inducing HPV-specific CTLs [cytotoxic T lymphocytes] and anti-tumor responses.
"Recently, we developed a novel recombinant SFV construct encoding a relatively stable fusion protein of HPV16 E6 and E7 under control of a translational enhancer derived from the SFV capsid protein," said T. Daemen and colleagues, University of Groningen.
Writing in the journal Vaccine, the researchers were able to show that established tumors were reduced and/or eliminated in mice immunized with the improved vector (Eradication of established HPV16-transformed tumours after immunisation with recombinant Semliki Forest virus expressing a fusion protein of E6 and E7. Vaccine, 2003;21(11-12):1082-1088).
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Source: HighBeam Research, Recombinant SFV expressing fusion protein eliminated tumors in...