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HIV specific immune responses boosted by structured treatment interruptions.(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- Results of a study by Immune Response Corp. scientists back the idea that HIV specific immune responses play a role in control of viremia.
"The immunologic correlates associated with control of viremia in HIV disease are poorly understood. We hypothesized that structured antiviral drug treatment interruptions could be utilized to better understand the relationship between HIV specific immunity and viral replication," said R.B. Moss and colleagues.
Thirteen HIV-1 chronically infected patients on highly active antiretroviral treatment (HAART) who had received therapeutic HIV immunizations and 12 who didn't underwent two 8-week antiviral structured treatment interruptions.
Moss and colleagues reported "that p24 gag antigen (np24) stimulated MIP-1beta levels and T-helper immune responses prior to antiviral drug discontinuation were associated with control of viremia. Stronger and earlier production of gag peptide stimulated gamma interferon was observed in the immunized ...
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Source: HighBeam Research, HIV specific immune responses boosted by structured treatment...