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Genome sequences of three South African HIV type 1 subtype C isolates characterized.
2003 APR 16 - (NewsRx.com & NewsRx.net) -- The near-full length genome sequences of three South African human immunodeficiency virus (H(V) type 1 subtype C isolates have been characterized.
G.M. Hunt and colleagues at the University of Witwatersrand, National Institute of Communicable Diseases, AIDS Virus Research Unit, isolated "proviral DNA ... from primary cultures of three South African R5 isolates and the near-full length genome amplified by PCR [polymerase chain reaction]."
They cloned the PCR product "into the pCR-XL-TOPO vector and a representative clone from each isolate sequenced by primer walking," the researchers explained.
"Phylogenetic analysis showed all three clones clustered within subtype C with a bootstrap value of 100%, and no recombination with other subtypes was identified by distance scan and bootscan analysis," reported Hunt and team.
"Analysis of the potential coding regions revealed premature truncations of the second rev exon but no other potential structural distortions nor frameshift mutations in the open reading frames.
"All the clones contained three potential NF-kappaB binding sites, a feature unique to subtype C viruses," they said.
"The ...
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