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Oral vaccine conveys immunity in murine study.(type F botulinum toxin prevention)(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- A study in mice has demonstrated that an oral vaccine conveyed immunity against botulinum toxin type F.
S. Foynes and colleagues, University of London Imperial College of Science, Technology & Medicine, evaluated "the utility of the htrA, pagC, and nirB promoters to direct the expression of the carboxy-terminal (H-C) fragment of botulinum toxin F (FHC) in Salmonella enterica var. typhimurium" in mice.
They reported, "Only low levels of serum antibody were induced after immunization, and some protection against botulinum toxin type F was demonstrated after oral immunization of mice with two doses of any of these recombinant Salmonella.
"Immunization with two doses of recombinant Salmonella expressing FHC from the htrA promoter gave the greatest protection, against up to 10,000 mouse lethal doses of botulinum toxin type F."
Foynes and colleagues concluded, "These results demonstrate the feasibility ...
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Source: HighBeam Research, Oral vaccine conveys immunity in murine study.(type F botulinum toxin...