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Infection spread inhibited by DNA immunization with C. trachomatis pgp3 gene.(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- In experiments with C3H/HeN mice, DNA immunization with the pgp3 gene of "Chlamydia trachomatis inhibited spread of the bacterial infection from the lower genital tract to the upper.
M. Donati and coauthors, University of Bologna, infected 300 "Chlamydia trachomatis pgp3 DNA-immunized and [300] non-immunized C3H/HeN mice ... by vaginal inoculation with infectious C. trachomatis serotype D elementary bodies (EB3s)."
They "[assessed] the spread of infection to the salpinges ... by cell culture isolation from tissue homogenates 7, 14, 21, 28, 35 and 42 days post-infection (p.i.)."
The researchers reported, "Overall, the pgp3-DNA immunization prevented salpinx infection in 94 (56%) mice, if compared with the 168 positive animals found among the non-immunized animals (p
"A group of negative control animals (i.e., mice immunized with plasmid DNA containing an irrelevant insert) was not protected, whereas all the mice of a positive immune control group (mice that had resolved a primary genital C. trachomatis infection) were resistant to re-infection," ...
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