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EFRH-phage immunization reduces beta-amyloid plaques in transgenic mouse brain.(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- EFRH-phage immunization reduced the number beta-amyloid plaques in the brain of transgenic mice in a study by Tel Aviv University molecular microbiologists.
"Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro," wrote D. Frenkel and colleagues.
Their recent work centered on a new immunization strategy: they used the "EFRH peptide displayed on the surface of the filamentous phage" as antigen.
Frenkel and coworkers reported that "the EFRH phage evoked effective autoimmune antibodies in amyloid precursor protein [V717I] (APP[V717I]) transgenic mice that recapitulate the amyloid plaques and vascular pathology of Alzheimer's disease (AD).
"The immunization provoked a considerable reduction in the number of Abeta amyloid plaques in ...
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Source: HighBeam Research, EFRH-phage immunization reduces beta-amyloid plaques in transgenic...