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Pre-pro sequence needed for DNA vaccine to induce dust mite allergen antibodies.(Brief Article)
2003 APR 16 - (NewsRx.com & NewsRx.net) -- A pre-pro sequence is necessary for a DNA vaccine encoding the dust mite allergen, Der p 1, to induce antibody response, found researchers in Singapore.
"The mite protein Der p 1 is a major trigger of allergy and atopic asthma worldwide, and thus, a good vaccine candidate for allergy prevention. Since it is a cysteine protease, the catalytic effects of Der p 1 vaccination may be unpredictable. One approach to reduce this risk is to vaccinate with DNA encoding enzymatically inactive forms of Der p 1," said C.B. Wolfowicz and colleagues.
In their study, "... Der p 1 DNA without its native pre-pro sequences potently induced Der p 1-specific antibodies, as long as its pre-sequence was substituted by another leader sequence.
"Without any pre-pro sequence, the same DNA fragment was well expressed but failed to induce significant level of anti-Der p 1 ...
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Source: HighBeam Research, Pre-pro sequence needed for DNA vaccine to induce dust mite allergen...