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Selection pressure has little effect on process.(of HIV transmission)
2003 APR 10 - (NewsRx.com & NewsRx.net) -- Selection pressure has little effect on the process of vertical HIV transmission.
According to recent research from Belgium, "although several virologic and immunologic factors associated with an increased risk of perinatal human immunodeficiency virus type I (HIV-1) transmission have been described, the mechanism of mother-to-child transmission is still unclear."
"More specifically, the question of whether selective pressures influence the transmission remains unanswered," wrote C. Verhofstede and coauthors at the State University of Ghent Hospital, who conducted a study to "assess the genetic diversity of the transmitted virus after in utero transmission and after peripartum transmission and to compare the viral heterogeneity in the child with the viral heterogeneity in the mother."
"To allow a very accurate characterization of the viral heterogeneity in a single sample, limiting-dilution sequencing of a 1,016-bp fragment of the env gene was performed," Verhofstede and coworkers said. "Thirteen children were tested, including six with in utero infections and seven with peripartum infections. Samples were taken the day after birth and at the ages of six and 14 weeks."
"A homogeneous virus population was seen in six (46.2%) infants, of whom two were infected in utero and four were infected peripartum," study data showed. "A more heterogeneous virus ...
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- Selection pressure has little effect on process.(HIV transmission)
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Source: HighBeam Research, Selection pressure has little effect on process.(of HIV transmission)