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RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway.
2003 APR 10 - (NewsRx.com & NewsRx.net) -- RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway.
According to recent research from the United States, "Previous studies indicated that the antiprogestin RU486 could directly inhibit the growth of normal and malignant human endometrial cells. However, the mechanism by which this occurs is poorly understood. In this study we explore further details of endometrial cell growth regulation by RU486."
"Gel shift assays using the endometrial cell line EM42 demonstrated that RU486, at concentrations ranging from 20-100 microM, significantly stimulated the cellular binding activity of NF-kappaB while having little effect on activating protein-1 (AP-1) binding. This effect on NF-kappaB binding was blocked in the presence of the NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC). The data also showed that the activity of RU486 on NF-kappaB binding correlated with the ability of this compound to induce apoptosis of EM42 cells. To investigate a cause and effect relationship between these two phenomena, we evaluated the effects of RU486 treatment on the expression of 2 apoptosis related genes, bax and bcl-2, known to be regulated through NF-kappaB binding on their promoter. RT-PCR demonstrated that RU486 significantly induced bax mRNA levels, while suppressing mRNA of bcl-2. Alteration of these genes by RU486 was inhibited in the presence of 100 gm PDTC. Correspondingly, PDTC antagonized the ability of RU486 ...
- Prevalence of Normal Endometrial Cells in Pap Smears.
- Magazine article from: OB/GYN Clinical Alert January 1, 2001 700+ words
Synopsis: The finding of normal endometrial cells on a postmenopausal Pap smear is...DETERMINE IF the presence of normal endometrial cells on a routinely obtained Papanicolaou...percent of these women had normal endometrial cells on their smears. The comparison...
- Endometrial cells can originate from donor-derived bone marrow cells.
- Newspaper article from: Biotech Week July 28, 2004 700+ words
2004 JUL 28 - (NewsRx.com & NewsRx.net) -- Donor-derived endometrial cells were detected in biopsy samples of four women who received bone marrow transplants to treat leukemia, according to a Yale University...
- Isoflavones exert estrogen modulatory effects on endometrial cells.
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
2003 FEB 25 - (NewsRx.com & NewsRx.net) -- "Endometrium consists of different cell populations such as epithelial and stromal cells and is mainly regulated by sex steroids. Isoflavones are plant derived estrogenic compounds that have estrogenic and antiestrogenic properties in a cell specific
- RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway.
- Newspaper article from: Proteomics Weekly April 7, 2003 700+ words
...by involving the NF-kappa B signaling...malignant human endometrial cells. However, the...apoptosis of human endometrial cells by RU486 involves stimulation of NF-kappaB binding...inhibition of human endometrial cells involves the nuclear...
- Studies from University of Arkansas further understanding of reproduction.
- Newspaper article from: Life Science Weekly August 19, 2008 700+ words
...receptors for estrogen and progesterone in endometrial cells in vivo and in vitro," scientists in...genes, and nuclear factor-kappaB (NF-kappaB) DNA binding activity in myometrium...expression patterns of nuclear PGR-A and NF-kappaB p65/RELA relative to WT mice...
- Importance of NF-[Kappa]B in rheumatoid synovial tissues: in situ NF-[Kappa]B...
- Magazine article from: Annals of the Rheumatic Diseases Yamasaki, S Kawakami, A Nakashima, T Nakamura, H Kamachi, M Honda, S Hirai, Y Hida, A Ida, H Migita, K Kawabe, Y Koji, T Furuichi, I Aoyagi, T Eguchi, K July 1, 2001 700+ words
...Objectives--To examine whether inhibition of NF-[Kappa]B induces apoptosis of human...proliferating cell nuclear antigen (PCNA), NF-[Kappa]B, and the presence of apoptotic...synovial cells was induced by inhibition of NF-[Kappa]B nuclear translocation by Z...
- A picture of NF-[kappa]B signaling: approaching from different directions,...
- Magazine article from: The Scientist Constans, Aileen March 28, 2005 700+ words
The transcription factor NF-[kappa]B exists in unstimulated cells...bound to inhibitory I[kappa]B protein. NF-[kappa]B has received a great deal...And the molecules associated with the NF-[kappa]B signaling pathway are prime...
- Melatonin reduces inflammatory injury through inhibiting NF-[kappa]B activation...
- Magazine article from: Mediators of Inflammation Li, Jun-Hua Yu, Jie-Ping Yu, Hong-Gang Xu, Xi-Ming Yu, Liang-Liang Liu, Jin Luo, He-Sheng January 1, 2005 700+ words
...IBD, which are regulated by activation of NF-[kappa]B. The aim of this study was...and inhibits proinflammatory molecule and NF-[kappa]B in rats with colitis. Rat colitis model was established by TNBS enema. NF-[kappa]B p65, TNF-[alpha], ICAM...
- Is NF-[kappa]B a useful therapeutic target in rheumatoid arthritis? (Report).
- Magazine article from: Annals of the Rheumatic Diseases Feldmann, M Andreakos, E Smith, C Bondeson, J Yoshimura, S Kiriakidis, S Monaco, C Gasparini, C Sacre, S Lundberg, A Paleolog, E Horwood, NJ Brennan, FM Foxwell, BMJ November 1, 2002 700+ words
There is increasing evidence that NF-[kappa]B is a major, if not the major...immunity. While this implies that blocking NF-[kappa]B might be therapeutically beneficial...this brief review we discuss the effects of NF-[kappa]B blockade in rheumatoid arthritis...
- Gastrin activates nuclear factor [kappa]B (NF[kappa]B) through a protein kinase...
- Magazine article from: Gut Ogasa, M. Miyazaki, Y. Hiraoka, S. Kitamura, S. Nagasawa, Y. Kishida, O. Miyazaki, T. Kiyohara, T. Shinomura, Y. Matsuzawa, Y. June 1, 2003 700+ words
...activation of nuclear factor [kappa]B (NF[kappa]B) in gastric epithelial cells...mediated signals leading to activation of NF[kappa]B. Methods: MKGR26 cells were...inhibitor rottlerin partially suppressed NF[kappa]B activation. However, the mitogen...
Source: HighBeam Research, RU486 inhibits growth of cells by involving the NF-kappa B signaling...