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Local interleukin-2 therapy inhibits proliferation of HPV-associated tumor.(human papillomavirus infection)
2003 APR 10 - (NewsRx.com & NewsRx.net) -- Local interleukin-2 therapy inhibits proliferation of HPV-associated tumor.
According to a study from Cuba, "Previous studies have shown inhibition of cervical cancer cell growth by treatment with high concentrations of IL-2. In the present study we evaluated the in vitro and in vivo effects of recombinant human IL-2 on HPV-associated tumor cells (3T3-16). Treatment of 3T3-16 cells with rhIL-2 for 72 h inhibited cell growth in a dose dependent manner and this effect was evidenced at nanomolar concentrations."
"These tumor cells expressed mRNA for beta and gamma subunits of the IL-2 receptor, which are required for signal transduction. In experiments to explore the effect of IL-2 on the growth of the HPV-associated tumor, mice received rhIL-2 through different routes: intraperitoneal; subcutaneous, at the tumor inoculation site; or subcutaneous, distant from the tumor inoculation site. An effective antitumor response was observed only in those animals that received IL-2 at the tumor site (p
Casana and coauthors concluded: "These results indicate the potential adequacy of therapeutic strategies based on local administration of rhIL-2 for cervical carcinoma, not only based on the ability of this cytokine ...
- Local interleukin-2 therapy inhibits proliferation of HPV-associated tumor.
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Source: HighBeam Research, Local interleukin-2 therapy inhibits proliferation of HPV-associated...