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Interleukin-6 promotes gynecological malignancy by activating angiogenesis.
2003 APR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - According to medical researchers in Taiwan, interleukin (IL)-6 is a major promoter of cervical cancer because of its influence on angiogenesis.
"IL-6 has received particular attention in the pathogenesis of cervical cancer, although the underlying mechanism remains elusive," said Lin-Hung Wei and colleagues, who work at National Taiwan University Hospital and College of Medicine.
The group's research, which included in vitro and in vivo analyses, shed more light on those underlying mechanisms, and deemed angiogenesis modulation an important element of IL-6-related tumorigenesis.
"The in vivo angiogenic assays showed that IL-6 increases angiogenic activity in human cervical cancer cells, an effect that is specifically associated with upregulation of vascular endothelial growth factor (VEGF)," the study authors wrote in Oncogene.
Investigators found they could inhibit IL-6-mediated angiogenesis in mice implanted with human tumors using a VEGF antibody. This signaled a strong relationship between IL-6, VEGF, and tumor angiogenesis, they said.
Wei's team also evaluated the influence of several signaling pathways downstream of IL-6 and its receptor, IL6-R. ...
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