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Whole-body hyperthermia and metronomic chemotherapy prevent cancer metastasis.
2003 APR 10 - (NewsRx.com & NewsRx.net) -- Whole-body hyperthermia and metronomic chemotherapy prevent cancer metastasis.
According to a study from the United States, "many women diagnosed with invasive breast cancer have undetected occult metastases at the time of their primary tumor diagnosis. The development and growth of these micro-metastases relies heavily on angiogenesis. Therefore, administering an angiogenesis-blocking treatment from the time of diagnosis could reduce the incidence of metastasis and, ultimately, increase patient survival."
"It is hypothesized that an antiangiogenesis strategy combining fever-range whole-body hyperthermia (FR-WBH) and metronomic chemotherapy could inhibit the development of metastatic disease with minimal toxicity. To test this theory, a low, daily dose of the topoisomerase I inhibitor irinotecan hydrochloride (CPT-11) was administered over a prolonged period of time to rats bearing the highly metastatic MTLn3 mammary adenocarcinoma primary tumor surgically excised on day 12 after implantation," described K. Sumiyoshi and coauthors, University of Texas, Houston Medical School.
"The metronomic CPT-11 was combined with long-duration, low-temperature, fever-range whole body hyperthermia ( FR-WBH). This systemic hyperthermia enhances chemotherapy-induced cytotoxicity as well as immunological activity," said researchers.
"Both the group treated with FR-WBH alone and the combined FR-WBH + CPT-11 group had delayed onset and reduced incidence of axillary lymph node metastases compared to control (p
"Interestingly, none of the therapies significantly affected inguinal lymph node metastases. Lung metastases were decreased by 36% at the time of death in rats treated with FR-WBH + CPT-11, ...
- Point-to-Multipoint Technology Adoption Forecast to Grow Rapidly in Wireless...
- Press release article from: Business Wire June 29, 2005 700+ words
...switching and management elements. It accounts for about one-fifth of the overall mobile network cost. A key dynamic within the WBH market is the increasing popularity of Point-to-Multipoint (PMP) solutions, instead of the traditional Point-to-Point...
- Research and Markets: How do the Economics of WBH Compare to Wireline...
- Press release article from: Business Wire July 5, 2005 700+ words
...this report include: --How do the economics of WBH compare to wireline technologies? --Do WBH technologies provide sufficient levels of reliability...What are the optimal deployment strategies for WBH? --Where is the breakeven point for investment...
- Jeffrey introduces WBH line of horizontal grinders.(Jeffrey Specialty Equipment...
- Magazine article from: Construction & Demolition Recycling July 1, 2006 700+ words
...Woodruff, S.C., has introduced an updated version of its WBH line of horizontal wood hogs. Designed to handle wood, construction...applications, according to the company. More information on the WBH line is available at www.jeffreycorp.com
- Starck withdraws proposal to acquire WBH
- Newspaper article from: Advanced Ceramics Report June 1, 1995 700+ words
...the Austrian tungsten company, Wolfram-Bergbau und Httengesellschaft mbH (WBH), located in Bergia. With the increase in sales volume through the acquisition of WBH, Starck says it saw an opportunity to intensify further its already substantial...
- Inmet Mining - Closing of WBH Sale Delayed.
- Press release article from: PR Newswire November 3, 1998 700+ words
(TSE/ME: IMN) TORONTO, Nov. 3 /CNW-PRN/ - Inmet Mining Corporation announced today that the proposed sale of its 100% interest in Wolfram Bergbau- und Hutten-GmbH, an Austrian tungsten producer, for C$50 million has not closed as scheduled on November 2. The purchaser, a private holding company,
- Whole-body hyperthermia and metronomic chemotherapy prevent cancer metastasis.
- Newspaper article from: Angiogenesis Weekly April 11, 2003 700+ words
...range whole-body hyperthermia (FR-WBH) and metronomic chemotherapy could...fever-range whole body hyperthermia ( FR-WBH). This systemic hyperthermia enhances...researchers. "Both the group treated with FR-WBH alone and the combined FR-WBH + CPT...
- FR-4 proliferation.(Material World)(proliferation of multilayer laminate...
- Magazine article from: CircuiTree Bergum, Erik April 1, 2007 700+ words
...ago when I started in this industry, there was a handful of multilayer laminate materials--FR-4, FR-5, polyimide, BT, and that was about it. FR-4 was then and is now the workhorse product for the industry. It was relatively easy to be...
- Fr Sinnott pleads for $2m ransom; Appearing frail, the 79-year-old smiles...
- Newspaper article from: The Mail on Sunday (London, England) November 1, 2009 700+ words
Byline: Valerie Hanley HOSTAGE priest Fr Michael Sinnott's religious order believes...will be freed unharmed by his captors. Fr Sinnott was abducted by six gunmen 21 days...the Philippines, the Irish Government and Fr Sinnott's order, the Columban Missionaries...
Source: HighBeam Research, Whole-body hyperthermia and metronomic chemotherapy prevent cancer...