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CCR5 genotype affects women's susceptibility to infection.(HIV susceptibility)(Brief Article)
2003 APR 10 - (NewsRx.com & NewsRx.net) -- Mutations in the gene for the HIV coreceptor CCR5 can protect women against HIV infection.
"Most studies of predominantly male cohorts found that individuals carrying a homozygous deleted form of the gene, Delta32, were protected against transmission, but protection did not extend to Delta32 heterozygotes," according to recent research from the United States.
"The role played by this mutation in HIV-1 transmission to women was studied in 2605 participants in the Women's Interagency HIV Study" by S. Philpott and coauthors at the New York State Department of Health.
"The Delta32 gene frequency was 0.026 for HIV-1-seropositive women and 0.040 for HIV-1-seronegative women, and statistical analyses showed that Delta32 heterozygotes were significantly less likely to be infected (odds ratio, 0.63 [95% confidence interval, 0.44-0.90])," they found. Thus, "the CCR5 Delta32 heterozygous genotype may confer partial protection against HIV-1 infection in women."
"Because Delta32 is rare in Africans and ...
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Source: HighBeam Research, CCR5 genotype affects women's susceptibility to infection.(HIV...