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Angiogenesis relates to recurrence in women with breast cancer.
2003 APR 10 - (NewsRx.com & NewsRx.net) -- Angiogenesis relates to recurrence in women with breast cancer.
"Tumor angiogenic activity is an important process linked to tumor growth, metastasis, and invasion. in the present study we investigated whether intratumoral microvessel density (MVD), as assessed with immonohistochemistry, is of prognostic relevance in a series of 77 breast cancer patients with node-negative disease," researchers in Greece report.
"The mean MVD in the hot spots ranged from 9 to 106 (median 31) vessels per x200 optical field. Patients were grouped into 3 categories of low (27 pts), medium (26 pts), and high (24 pts) MVD," wrote M.I. Koukourakis and colleagues, Tumor and Angiogenesis Research Group.
"Angiogenesis was not related to the primary tumor dimensions (T-stage) or the histology differentiation. An inverse association of MVD with estrogen receptor (ER) expression was noted (p=0.0007), while high MVD was directly related to c-erbB-2 overexpression (p=0.04) and high MIB1 proliferation index (p=0.02)," said researchers.
"In univariate and ...
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Source: HighBeam Research, Angiogenesis relates to recurrence in women with breast cancer.