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Aluminum hydroxide adjuvant affects sensitization toward OVA inhalation.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- An aluminum hydroxide adjuvant was able to modulate the development of sensitization or tolerance following repeated OVA inhalation in BALB/cJ mice.
"Anthropogenically induced exposures may, due to their adjuvant effect, promote development of sensitization to commonly occurring aeroallergens. No generally accepted model exists for determination of adjuvant effect of airborne substances. Therefore, BALB/cJ mice were exposed for 10 consecutive days with ovalbumin (OVA) solution, 25 mg/L-10 g/L (0.0025-1%) for 20 min/day, with and without the Al(OH)[subscript]3 adjuvant (0.5%)," researchers in Denmark report.
"Four days after the last aerosol exposure, no OVA specific IgE and only low IgG1 were produced," said Susanne Knoth Clausen and collaborators at the National Institute of Occupational Health and National University Hospital in Copenhagen. "Subsequent parenteral OVA administration showed that the 10 g/L solution induced full tolerance of the IgE response, whereas only partial tolerance was apparent with 25 mg/L OVA. The AI(OH)[subscript]3 adjuvant counteracted development of tolerance that was fully prevented at the 25 mg/L OVA concentration. Development of IgG1 was increased in a concentration-dependent manner with 500 mg/L-10 g/L OVA. No increase occurred at the 25 mg/L level, but addition of AI(OH)[subscript]3 increased IgG1 production to the same level as the higher OVA concentrations. Concentrations from 1.25 mg/L to 10 g/L OVA were studied with ten exposures followed by ...
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Source: HighBeam Research, Aluminum hydroxide adjuvant affects sensitization toward OVA...