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ACAM2000 completes phase I trial.(Brief Article)

Vaccine Weekly

| April 09, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 APR 9 - (NewsRx.com & NewsRx.net) -- Acambis, plc, (ACAM) announced that it has completed a phase I trial of its smallpox vaccine, ACAM2000.

The trial assessed the safety, tolerability, and immunogenicity of ACAM2000 in adult subjects who had not previously been inoculated against smallpox. All 100 subjects in the open-label trial were vaccinated with ACAM2000.

The currently accepted indication of protective immunogenicity in the case of smallpox vaccination is the development of a pock-mark on the skin, known as a "take." This "take" was the primary endpoint of the trial and was seen in 99% of the ...

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