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Virus-cross-HIV-1-neutralizing antibodies induced by in vivo expression system.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- Primary virus-cross-reactive human immunodeficiency virus type 1-neutralizing antibodies were induced in small animals using an alphavirus-derived in vivo expression system.
According to a study from the United States and China, "We have studied the induction of neutralizing antibodies by in vivo expression of the human immunodeficiency virus type I (HIV-1) envelope by using a Venezuelan equine encephalitis virus (VEE) replicon system with mice and rabbits. The HIV-1 envelope, clone R2, has broad sensitivity to cross-reactive neutralization and was obtained from a donor with broadly cross-reactive, primary virus-neutralizing antibodies (donor of reference serum, HIV-1-neutralizing serum 2 [HNS2])."
"It was expressed as gp160, as secreted gp140, and as gp160 DeltaCT with the cytoplasmic tail deleted," reported Ming Dong and collaborators at the Uniformed Services University of the Health Sciences, Henry M. Jackson Foundation for the Advancement of Military Medicine, and Johns Hopkins University in the United States and the National AIDS Reference Laboratory in China. "gp140 was expressed in vitro at a high level and was predominantly uncleaved oligomer. gp160 DeltaCT was released by cells in the form of membrane-bound vesicles. gp160 DeltaCT induced stronger neutralizing responses than the other forms. Use of a helper plasmid for replicon particle packaging, in which the VEE envelope gene comprised a wild-type rather than a host range-adapted sequence, also enhanced immunogenicity."
"Neutralizing activity fractionated with immunoglobulin G," said the investigators. "This activity was cross-reactive among a panel of five nonhomologous primary clade B strains and a Chinese clade C strain and minimally reactive ...
- Virus-cross-HIV-1-neutralizing antibodies induced by in vivo expression system.
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