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Rapid generation of antigen-presenting cells from leukemic blasts developed.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- A method for the rapid generation of antigen-presenting cells from leukemic blasts in acute myeloid leukemia has been developed.
"The ability of acute myeloid leukemia (AML) cells to acquire dendritic cell (DC)-like characteristics in vitro with a rapid culture method based either on the phorbol ester PMA or calcium ionophores has been studied in comparison to conventional AML-DC cultures with the cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), interleukin-3 (IL-3), SCF, FLT3-L, and IL-4. In all AML patients, antigen-presenting cells (APC) could be generated from leukemic cells in two days by incubation with PMA or calcium ionophore (A23187 or ionomycin) in the presence as well as in the absence of IL-4," researchers in Netherlands report.
"In 30 out of 36 patients APC could be generated after two weeks of culture in cytokine-enriched medium," stated Theresia M. Westers and collaborators at the VU University Medical Centre in Amsterdam. "AML-APC cultured with PMA or calcium ionophores immunophenotypically and functionally were at a more mature stage than those cultured in cytokine-enriched medium. The most mature APC were generated by calcium ionophore A23187 plus IL-4, as evidenced by the higher expression of CD40, CD80, CD86, and HLA-DR. Autologous T cell mediated cytotoxicity towards AML blast cells in vitro was ...
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Source: HighBeam Research, Rapid generation of antigen-presenting cells from leukemic blasts...