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HPV16-associated, MHC class I+ tumors more susceptible than class I- to therapy.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- Chemoimmunotherapy was more effective in mice carrying HPV16-associated, MHC class I+ tumors than in those carrying and class I- tumors.
According to recent research from Czech Republic, "The effectiveness of chemoimmunotherapy with ifosfamide derivative CBM-4A and recombinant IL-2, IL-12, GM-CSF, or genetically modified, cytokine-producing tumor vaccines was examined in mice carrying HPV16-associated, MHC class I+ (TC-1), and MHC class P (MK16) tumors. Intraperitoneal treatment of TC-1 or MK16 tumor-bearing g mice with CBM-4A produced a significant tumor-inhibitory effect."
"When the i.p. treatment of the MHC class I+ TC-1 tumor-bearing mice with CBM-4A was followed by peritumoral s.c. administration of IL-2, IL-12, or both cytokines, the growth of TC1 tumors was inhibited more vigorously than after the chemotherapy alone," reported M. Indrova and colleagues at the Academy of Sciences of the Czech Republic. "In contrast, when the i.p. treatment of the MHC class P MK16 tumor-bearing mice with CBM-4A was followed by peritumoral s.c. administration of IL-2 or IL-12, the cytokine therapy had no potentiating effect. The only potentiating effect of the MK16 tumor immunotherapy was obtained when the i.p. CBM-4A pretreatment was followed by peritumoral s.c. administration of IL-2 plus IL-12."
"In further experiments, the TC-1 and MK16 tumor-bearing mice were i.p. pretreated with CBM-4A and then injected s.c., peritumorally, with genetically modified, IL-2 or GM-CSF-producing MK16 tumor vaccines," the researchers stated. "Whereas both genetically modified tumor vaccines produced a substantial tumor-inhibitory effect in mice carrying TC-1 tumors, no effect of the vaccines was ...
- HPV16-associated, MHC class I+ tumors more susceptible than class I- to therapy.
- Newspaper article from: Cancer Weekly April 8, 2003 700+ words
...recombinant IL-2, IL-12, GM-CSF...HPV16-associated, MHC class I+ (TC-1...treatment of the MHC class P MK16 tumor-bearing...administration of IL-2 or IL-12...HPV16-associated, MHC class I+ and class I...potentiated with IL-2, IL-12, GM...
- HPV16-associated, MHC class I+ tumors more susceptible than class I- to...
- Newspaper article from: Virus Weekly April 8, 2003 700+ words
...recombinant IL-2, IL-12, GM-CSF...HPV16-associated, MHC class I+ (TC-1...treatment of the MHC class P MK16 tumor-bearing...administration of IL-2 or IL-12...HPV16-associated, MHC class I+ and class I...potentiated with IL-2, IL-12, GM...
- Ii-Key/MHC class II epitope hybrid peptide vaccines show promise for HIV.
- Newspaper article from: AIDS Vaccine Week January 26, 2004 700+ words
...polymethylene bridge to MHC class II epitopes of HIV gp160...potent responses to two MHC class II epitopes, HIV gp160...peptides, as measured in IL-4 and IFN-gamma ELISPOT...increased. The Ii-Key/MHC class II epitope hybrid acts on...
- Antigen Express Announces Phase I SBIR Grant for Development of MHC Class II...
- Press release article from: PR Newswire April 5, 2001 700+ words
...prostate cancers do not express MHC Class II. Using a highly aggressive...researchers aim to first induce MHC Class II and suppress Ii protein...i.e., GM-CSF and IL-2), will be used by...helper T-cells require MHC Class II presented antigens...
- Adenovirus vectors effectively deliver MHC class I and II antigens.
- Newspaper article from: AIDS Weekly February 10, 2003 700+ words
...histocompatibility complex (MHC) class I- and class II-restricted...costimulatory molecules, IL-12 p40 production and...presented in association with MHC class II molecules for activation...DCs with rAd encoding MHC class I and class II-restricted...
- MHC class I-restricted alloreactive CD4 T cells identified.
- Newspaper article from: Drug Week July 9, 2004 700+ words
...NewsRx.com & NewsRx.net) -- A set of MHC class I-restricted alloreactive CD4 cells has been...recognize major histocompatibility complex (MHC) class II molecules, MHC class I-reactive CD4+ T cells have occasionally...
- Aberrant MHC class II expression not sufficient to induce thyroid autoimmunity.
- Newspaper article from: Blood Weekly July 1, 2004 700+ words
...com & NewsRx.net) -- Aberrant MHC class II expression alone is not sufficient...of major histocompatibility complex (MHC) class II molecules on thyrocytes has been demonstrated...However, the role of this aberrant MHC class II in disease development is controversial...
- Exosomes transfer functional MHC class I/peptide complexes to dendritic cells.
- Newspaper article from: Immunotherapy Weekly April 28, 2004 700+ words
...derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells...eradication. Because DC can secrete MHC class I-bearing exosomes, we addressed whether...subserve the DC function consisting in MHC class I-restricted, peptide-specific CTL...
Source: HighBeam Research, HPV16-associated, MHC class I+ tumors more susceptible than class I-...