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Subunit-adjuvanted influenza vaccine more immunogenic than split vaccine.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- A subunit-adjuvanted influenza vaccine was more immunogenic in elderly subjects compared with an inactivated split virion influenza vaccine.
"A randomized, open study was carried out among an elderly population in order to compare the reactogenicity and immunogenicity of an inactivated, split virion influenza vaccine (Vaxigrip, Aventis Pasteur MSD, Lyon, France) with that of an MF59-adjuvanted, subunit vaccine (Fluad, Chiron Vaccines, Siena, Italy). Both vaccines contained the three strains: A/Sydney/5/97 (H3N2), A/Beijing/262/95 (H1N1), and B/Beijing/184/93, recommended by the WHO for the 1998-1999 influenza season," researchers in Italy report.
"A total of 2,150 subjects were vaccinated and included in the reactogenicity analysis," said S. Squarcione and collaborators at Osped Lazzaro Spallanzani and Aventis Pasteur MSD S.p.A. "A total of 1,076 subjects received Vaxigrip (age 73.3[+ or -]5.9 years, 49.6% men) and 1,074 subjects received Fluad(age 73.4[+ or -]5.9 years, 52.3% men). All subjects were kept under medical observation for 30 minutes after vaccination, in order to check any immediate local and/or systemic reaction. A self monitoring diary card was given to all subjects to collect any local and/or systemic reaction occurring during the three days following the vaccination, any adverse event occurring between vaccination day and 21st day post-vaccination and any medication taken during the study period."
"A total of 1,186 subjects were included in the immunogenicity analysis," the investigators reported. "A total of 591 subjects received Vaxigrip (age 73.4[+ or -]5.6 years, 52.3% men) and 595 subjects received Fluad (age 73.8[+ or -]5.9 years, 55.8% men). Blood samples were collected pre- and 21 days post-vaccination and were analyzed by the hemagglutination inhibition assay."
Squarcione and associates found, "In terms of reactogenicity both vaccines were generally well ...
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