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Influenza vaccines from two facilities have similar safety and efficacy profiles.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- The safety and immunogenicity profiles of live-attenuated influenza vaccines blended and filled at two manufacturing facilities were similar.
According to recent research from Australia, "This study was designed to compare the safety and immunogenicity of a trivalent live-attenuated, cold-adapted influenza vaccine (CAIV-T) blended and filled at two different manufacturing facilities (Medeva and Aviron-PA). The vaccines contained approximately 10[superscript]7 TCID[subscript]50 (median tissue culture infectious dose) of each of the three recommended 1997-1998 influenza vaccine components, A/Shenzhen/227/95 (H1N1) (A/Bayem/7/95 (H1N1)-like strain), A/Wuhan/359/95 (H3N2), and B/Ann Arbor/1/94 (B/Beijing/184/93-like strain)."
"Two hundred and twenty-five healthy Australian children aged 12-42 months were enrolled and randomized in a 3:2 ratio to receive CAIV-T blended and filled either at Medeva or at Aviron-PA," said Terry Nolan and collaborators at the University of Melbourne, the Murdoch Children's Research Institute, and MedImmune Vaccines. "Two doses of CAIV-T were given 4-6 weeks apart as an intranasal spray. Three blood specimens were collected (immediately before doses one and two, and 28[+ or -]5 days following dose two) for measuring hemagglutination inhibition (HAI) antibody responses. Adverse events occurring within 10 days and serious adverse events occurring within 42 days were collected. Serum HAI antibody levels were measured against the three vaccine strains. Equivalent immunogenicity between the two vaccine groups was pre-specified as: (1) within 20% difference in seroconversion rates (HAI titers ...
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Source: HighBeam Research, Influenza vaccines from two facilities have similar safety and...