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IgA response greater with intranasal than intramuscular vaccine delivery.
2003 APR 9 - (NewsRx.com & NewsRx.net) -- Intranasal delivery of an influenza vaccine stimulated a greater IgA response than did intramuscular delivery vaccine delivery in elderly residents of a nursing home.
"Intramuscular (IM) influenza vaccines are only 30-40% effective in preventing clinical illness among the elderly, and their effectiveness in eliciting mucosal response may be even lower. The aim of the present study was to evaluate the immunological effect of a novel inactivated intranasal (IN) trivalent whole influenza virus vaccine among nursing-home elderly," researchers in Israel report.
"Twenty-one institutionalized elderly subjects were vaccinated IN with an inactivated novel vaccine, twice, 21 days apart, and with no adverse effects," stated Mordechai Muszkat and colleagues at Hebrew University Hadassah Medical School and Hadassah University Hospital. "Twenty-two subjects were vaccinated once with a commercial IM vaccine. Viral strains used in the 1998/9 vaccine (20 micrograms of each per dose) were A/Beijing/262/95, A/Sydney/5/97, and B/Harbin/7/94. Serum antibodies (IgG and IgM) and nasal IgA were determined by the hemagglutination inhibition (HI) test and enzyme-linked immunosorbent assay (ELISA), respectively."
The researchers found, "Mucosal antibody response to the three vaccine strains was detected in 47.6-71.4% and 18.1-31.8% of IN and IM immunized subjects, respectively. Serum antibody response to the three antigens tested was detected in 20.0-61.9% and 18.2-72.7% of IN and IM immunized subjects, respectively. Seroconversion was not ...
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Source: HighBeam Research, IgA response greater with intranasal than intramuscular vaccine...