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Inhibition of iASPP oncoprotein could improve tumor destruction.(in breast cancer)
2003 APR 3 - (NewsRx.com & NewsRx.net) -- Inhibition of iASPP oncoprotein could improve tumor destruction.
"We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have further shown that 53BP2, which corresponds to a C-terminal fragment of ASPP2, acts as a dominant negative inhibitor of p53," researchers in England reported.
"Hence, an inhibitory form of ASPP resembling 53BP2 could allow cells to bypass the tumor-suppressor functions of p53 and the ASPP proteins. Here, we characterize such a protein, iASPP (inhibitory member of the ASPP family), encoded by PPP1R13L in humans and ape-1 in Caenorhabditis elegans," wrote D. Bergamaschi and colleagues, University of London Imperial College of Science and Technology, School of Medicine.
"iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C elegans or human cells, respectively, induces p53-dependent apoptosis. Moreover, iASPP is an oncoprotein that cooperates with Ras, E1A and E7, but not mutant p53, to transform cells in ...
- Inhibition of iASPP oncoprotein could improve tumor destruction.
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