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Topiramate effective for binge eating in obese adults.
2003 APR 3 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The frequency of binge eating was significantly lower in obese patients treated with topiramate than in similar patients who received a placebo, according to a report in the American Journal of Psychiatry.
"Binge eating disorder is associated with obesity," said Susan L. McElroy and colleagues at the University of Cincinnati. "Topiramate is an antiepileptic agent associated with weight loss. The objective of this study was to evaluate topiramate in the treatment of binge eating disorder associated with obesity."
The investigators randomly assigned 61 obese patients (53 women, 8 men) with binge eating disorder to receive either 25-600 mg/day topiramate (n=30) or a placebo (n=31) for 14 weeks. The median dose of topiramate was 212 mg/day.
Patients in the topiramate group experienced significant reductions in binge frequency (topiramate: 94%, placebo: 46%), binge day frequency (topiramate: 93%, placebo: 46%), body weight, and body mass index compared with patients in the placebo group. Scores on the Clinical Global Impression severity scale and the Yale-Brown Obsessive Compulsive Scale also were lower in the treated patients.
Patients who completed the 14-week regimen of topiramate lost an average of 5.9 kg.
However, the topiramate caused adverse events severe enough to cause six patients in the treatment to drop out of the study. The most common complaints were headache and paresthesias. Three patients in the placebo ...
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Source: HighBeam Research, Topiramate effective for binge eating in obese adults.