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Thymidylate synthase and thymidine are valid markers for selecting therapy.(for breast cancer)
2003 APR 3 - (NewsRx.com & NewsRx.net) -- Thymidylate synthase and thymidine are valid markers for selecting breast cancer therapy.
According to a study from Japan, "thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor, and has an angiogenic activity in experimental models and human solid tumors."
"A critical step in the de novo pathway of DNA synthesis is the production of the pyrimidine nucleotide dTMP from dump and this reaction is catalyzed by thymidylate synthase (TS). Both dThdPase and TS levels seemed to be related to response to 5-fluorouracil (5-FU) therapy in different types of human solid tumors," stated O. Ogura and coauthors, Tohoku University, Institute of Development, Aging, and Cancer.
"The present study evaluated dThdPase and TS expression levels by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR), using a same set of 39 breast carcinoma tissues for both methods. An inverted-relationship in the expression levels of TS and dThdPase was observed," said investigators.
"Further, immunohistochemical analysis may be a better tool than analysis by RT-PCR in detection of dThdPase and ...
- Thymidylate synthase mRNA predicts shorter survival in breast cancer.
- Newspaper article from: Cancer Weekly April 6, 2004 700+ words
...expression of thymidylate synthase mRNA is associated...patients with breast cancer. "Thymidine...TP), thymidylate synthase (TS) and...phosphorylase, thymidylate synthase and dihydropyrimidine...areas of Breast Cancer Prognosis...
- Thymidylate synthase and thymidine are valid markers for selecting therapy.
- Newspaper article from: Angiogenesis Weekly April 4, 2003 700+ words
...net) -- Thymidylate synthase and thymidine...selecting breast cancer therapy...catalyzed by thymidylate synthase (TS...Expression of thymidylate synthase and thymidine...Angiogenesis, Breast Cancer, Cell Biology...
- Thymidylate synthase expression not linked to colon cancer phenotype.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...exists between polymorphisms in the thymidylate synthase gene or the expression of thymidylate synthase mRNA and the microsatellite instability...cellular target of 5-FU therapy, thymidylate synthase. Polymorphisms in the 3'- and...
- Thymidylate synthase can transform murine cells to malignancy.
- Newspaper article from: Cancer Gene Therapy Week July 5, 2004 700+ words
...amp; NewsRx.net) -- Elevated thymidylate synthase levels might be linked to tumor...that forced overexpression of human thymidylate synthase transforms immortalized murine cells...possibility that elevated levels of thymidylate synthase noted in some human malignancies...
- Thymidylate synthase antisense blocks the oncogenic properties of colon cancer.
- Newspaper article from: Biotech Week February 11, 2004 700+ words
...com & NewsRx.net) -- Thymidylate synthase antisense blocks the oncogenic properties...large part, by inhibition of the thymidylate synthase (TS), an essential DNA synthetic...of Oncology (The transfection of thymidylate synthase antisense suppresses oncogenic properties...
- Inhibiting cancer enzyme.(Patents)(thymidylate synthase properties)(Brief...
- Magazine article from: Chemistry and Industry December 4, 2006 700+ words
...100 nucleotides long and target the mRNA of the enzyme thymidylate synthase. They are an exact match for the mRNA and bind to it...researchers now plan clinical trials in conjunction with other thymidylate synthase inhibitors such as 5-fluorouracil. European Patent...
- Two expressed enzyme levels can predict the efficacy of...
- Newspaper article from: Cancer Weekly April 8, 2003 700+ words
...chemotherapy. "Dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) gene expressions in metastatic colorectal cancer...Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters...
- An investigation of a thymidylate synthase residue at position 163 in...
- Magazine article from: Bulletin of the South Carolina Academy of Science Demara, Megan January 1, 2003 700+ words
...different ways. However, most cancers come down to the principle of neoplasms metastasizing and creating tumors. Thymidylate synthase (TS) is an enzyme that is necessary for cellular proliferation. Perhaps it has some effect on the cause or...
- Stabilization of the Inactive Conformation of Human Thymidylate Synthase.(Brief...
- Magazine article from: Bulletin of the South Carolina Academy of Science Johnson, Saphronia R. Berger, Sondra H. Phan, Jason Lebioda, Lukasz January 1, 2001 700+ words
Thymidylate synthase (TS) is a homodimer of approximately 72 kDa which catalyzes the reductive methylation of 2-deoxyuridine monophosphate (dUMP...
- Agouron Pharmaceuticals allowed to test AG-331. (thymidylate synthase...
- Newspaper article from: Cancer Weekly February 1, 1993 700+ words
...Using proprietary methods for drug design, Agouron scientists engineered AG-331 to block the activity of thymidylate synthase (TS) - an enzyme required for the rapid proliferation of cancer cells. In studies first reported in 1992 at...
Source: HighBeam Research, Thymidylate synthase and thymidine are valid markers for selecting...