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Tamoxifen and a farnesyl transferase inhibitor can have synergistic effects.(breast cancer treatment)
2003 APR 3 - (NewsRx.com & NewsRx.net) -- Tamoxifen and a farnesyl transferase inhibitor can have synergistic effects.
"Farnesyl transferase inhibitors (FTIs) serve to specifically inhibit farnesyl isoprenoid lipid modification of proteins. Although originally developed as anti-Ras oncoprotein drugs, it now appears that these compounds function independently of Ras. FTIs have been shown to inhibit transformation by a variety of mechanisms, including apoptosis involving cytochrome c release from mitochondria," researchers in the United States report.
"Tamoxifen exhibits both antiestrogenic and estrogenic properties and is widely used as an estrogen antagonist for the treatment of estrogen receptor (ER) positive human breast tumors. Tamoxifen can induce ER-dependent apoptosis in human breast tumor cells by a mechanism involving the Bcl2/mitochondrial arm of the apoptotic machinery. Since tamoxifen and FTIs may stimulate distinct components of the mitochondrial-based apoptotic machinery, we reasoned that their effects might be synergistic.
"Here we show that antiestrogens and an FTI (FTI-277) synergize to inhibit cell growth and enhance cell death in ER positive, human breast tumor cell lines. However, the drugs exhibited only additive effects on an ER negative cell line. Analysis of treated ER positive ...
- Tamoxifen and a farnesyl transferase inhibitor can have synergistic...
- Newspaper article from: Cancer Weekly April 1, 2003 700+ words
...their study in Breast Cancer Research and...Tamoxifen and the farnesyl transferase inhibitor FTI...cell lines. Breast Cancer Res Treat, 2003...Cell Biology, Breast Cancer, Tamoxifen, Farnesyl Transferase Inhibitors...
- Tamoxifen and a farnesyl transferase inhibitor can have synergistic effects.
- Newspaper article from: Clinical Oncology Week March 31, 2003 700+ words
...their study in Breast Cancer Research and...Tamoxifen and the farnesyl transferase inhibitor FTI...cell lines. Breast Cancer Res Treat, 2003...Cell Biology, Breast Cancer, Tamoxifen, Farnesyl Transferase Inhibitors...
- Farnesyl Transferase Inhibitors as Potential Anti-Cancer Agents to Headline...
- Press release article from: PR Newswire May 18, 2000 700+ words
...advances in anti-cancer research on farnesyl transferase, novel protein kinase, metalloproteinase...Institute. The presentations on farnesyl transferase inhibitors will be given by Dr...pre-clinical data that supports farnesyl transferase inhibitors' effectiveness against...
- The farnesyl transferase inhibitor R115777 has demonstrated clinical efficacy.
- Newspaper article from: Blood Weekly April 17, 2003 700+ words
...com & NewsRx.net) -- The farnesyl transferase inhibitor R115777 had demonstrated...investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients...study in Blood (Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid...
- The farnesyl transferase inhibitor R115777 has demonstrated clinical...
- Newspaper article from: Cancer Weekly April 15, 2003 700+ words
...com & NewsRx.net) -- The farnesyl transferase inhibitor R115777 had demonstrated...investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients...study in Blood (Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid...
- Farnesyl transferase inhibitors may have therapeutic potential.
- Newspaper article from: Cancer Weekly January 7, 2003 700+ words
...slightly affected. In contrast, treatment with the farnesyl transferase inhibitor, FPT III, induced apoptosis in MM cells in...microenvironment. Furthermore, we provide evidence that farnesyl transferase inhibitors might be useful for the development of novel...
- Patent No. 7,553,975 Issued on June 30, Assigned to Ipsen Pharma for Farnesyl...
- News wire article from: US Fed News Service, Including US State News July 3, 2009 700+ words
...Barry A. Morgan of Franklin, Mass., have developed farnesyl transferase inhibitors. The inventors were issued U.S. Patent...family of compounds capable of inhibiting the activity of farnesyl transferase." The original application was filed on May 30, 2006...
- Farnesyl transferase inhibitor can help patients at high risk for developing...
- Newspaper article from: Health & Medicine Week December 27, 2004 700+ words
...the other might; or they could potentially be used together." Zarnestra belongs to a group of drugs known as farnesyl transferase inhibitors, which block enzymes needed for the activation of cancer-promoting proteins. While the drug was...
Source: HighBeam Research, Tamoxifen and a farnesyl transferase inhibitor can have synergistic...