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Estrogen modulates cerebral angiogenic potential in middle-aged female rats.
2003 APR 3 - (NewsRx.com & NewsRx.net) -- Estrogen modulates cerebral angiogenic potential in middle-aged female rats.
According to a study from Japan, "the effect of postmenopausal estrogen replacement therapy (ERT) on the risk or severity of cerebrovascular disorders is as yet unclear, and the evidence for flow preservation being a mechanism of estrogen neuroprotection remains elusive."
"The authors examined whether estrogen-mediated flow-preserving neuroprotective mechanisms, if any, may involve its angiogenic action. This study was conducted using middle-aged (44 weeks) female rats because of the importance of aging in cerebrovascular disease in women," stated S. Jesmin and coauthors, Hokkaido University, School of Medicine.
"Middle-aged female rats were subjected to sham operation, ovariectomy, or ovariectomy with ERT. The anatomic cerebral capillary morphology showed a significant reduction in the total capillary density in the frontal cortex after ovariectomy. This was associated with marked decreases in protein and gene expression of vascular endothelial growth factor and its angiogenic receptors in cerebral vessels, as demonstrated by immunohistochemistry and in situ hybridization," according to study authors.
"The expression levels of both estrogen receptor (ER) subtypes, ERalpha and ERbeta, in cerebral vessels were significantly reduced after ovariectomy, but ERbeta ...
- Estrogen modulates cerebral angiogenic potential in middle-aged female rats.
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