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Pertussis toxin enhances Th1 responses by stimulation of dendritic cells.
2003 APR 2 - (NewsRx.com & NewsRx.net) -- The pertussis toxin enhances Th1 responses by stimulation of dendritic cells.
According to a study from the People's Republic of China, "Pertussis toxin (PTX) has been widely used as an adjuvant to induce Th1-mediated organ-specific autoimmune diseases in animal models. However, the cellular and molecular mechanisms remain to be defined. In this study, we showed that dendritic cells (DC) stimulated with PTX (PTX-DC) were able to substitute for PTX to promote experimental autoimmune uveitis (EAU)."
"EAU induced by PTX-DC revealed a typical Th1 response, characterized by high uveitogenic retinal Ag interphotoreceptor retinoid-binding protein (IRBP)-specific IFN-gamma and IL-12 production in the draining lymph nodes, as well as increased levels of anti-IRBP IgG2a and decreased levels of anti-IRBP IgG1 in the serum of IRBP-immunized mice," reported Wanqiu Hou and collaborators at the Chinese Academy of Sciences and Fudan University School of Medicine. "Furthermore, PTX-DC preferentially induced T cells to produce the Th1 cytokine, IFN-gamma. After being stimulated with PTX, DC exhibited up-regulation of MHC class II, CD80, CD86, CD40, and DEC205. PTX-DC had also increased allostimulatory capacity and IL-12 and TNF-alpha production. Serum IL-12 was increased in naive mice that received PTX-DC i.p. In addition, PTX activated extracellular signal-regulated kinase ...
- Psion Teklogix Launches PTX Print Mobile Printer Line.
- Press release article from: PR Newswire January 16, 2008 700+ words
...http://www.psionteklogix.com/), today announced the availability of its PTX Print Mobile printer line. The new printers, PTX Print PRINTABOUT, PTX Print MLP3030 and PTX Print MLP 3040, combine small size, lightweight and ruggedness...
- Angiotech Pharmaceuticals, Inc. - New study shows that Zilver(R) PTX(TM)...
- Press release article from: PR Newswire April 15, 2009 700+ words
...treated with Cook Medical's Zilver(R) PTX(TM) drug-eluting peripheral stent...reintervention at two-year follow up. The Zilver PTX Registry study, involving 792 patients...assessing the safety and efficacy of the Zilver PTX in treating PAD. The most recent results...
- Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European...
- Newspaper article from: Blood Weekly August 27, 2009 700+ words
...limited commercial launch of the Zilver[R] PTX[R] Drug-Eluting Peripheral Stent in...global study demonstrates that the Zilver PTX has the integrity, safety and durability...President and CEO of Angiotech. "The Zilver PTX stent platform has shown tremendous mechanical...
- Angiotech's Licensee, Cook Medical, Announces CE Mark Approval and European...
- Press release article from: PR Newswire August 11, 2009 700+ words
...limited commercial launch of the Zilver(R) PTX(R) Drug-Eluting Peripheral Stent in...global study demonstrates that the Zilver PTX has the integrity, safety and durability...President and CEO of Angiotech. "The Zilver PTX stent platform has shown tremendous mechanical...
- Angiotech announces commercial launch of Cook Medical's Zilver(R) PTX(TM)...
- Press release article from: PR Newswire April 4, 2008 700+ words
...with Cook Medical Inc.'s Zilver(R) PTX(TM) drug-eluting peripheral stent in...was treated in February 2008. The Zilver PTX is the world's first drug-eluting stent...vascular stent products, including the Zilver PTX. "Building on the success of our paclitaxel...
- NextSet's PTX Trading System Rolls-Out.
- Press release article from: Business Wire August 6, 2002 700+ words
...deployment of the Private Trading eXchange (PTX) system within ANZ Investment Bank, a...institutional and corporate clients. NextSet's PTX -- Private Trading eXchange -- is an online...Proposal (RFP), we chose NextSet's PTX system." "Partnering with NextSet has...
- New Zilver PTX Drug-Eluting Stent Now Available forEuropean Patients
- Newspaper article from: Wireless News September 23, 2009 700+ words
Wireless News 09-23-2009 New Zilver PTX Drug-Eluting Stent Now Available forEuropean...technology, said the new CE Marked Zilver PTX Drug-Eluting Peripheral Stent is expected...of its kind ever conducted, the Zilver PTX stent was shown to effectively bridge the...
- Something's coming, something good.(EDITOR'S NOTE)(PTX 2005)(Editorial)
- Magazine article from: Food Engineering Fassl, Joyce April 1, 2005 700+ words
...new strategic sales event ProcessTechnologyXchange (PTX). The entire agenda for PTX is built around your new capital equipment initiatives...challenges. As we discovered at the premier edition of PTX in 2004, these meetings can dramatically enhance...
