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Molecular characteristics of HIV-1 subtype C viruses elucidated.
2003 APR 2 - (NewsRx.com & NewsRx.net) -- A study of the molecular characteristics of human immunodeficiency virus type 1 subtype C viruses from KwaZulu-Natal, South Africa has resulted in implications for vaccine and antiretroviral control strategies.
According to recent research from South Africa, "The KwaZulu-Natal region of South Africa is experiencing an explosive outbreak of human immunodeficiency virus type 1 (HIV-1) subtype C infections. Understanding the genetic diversity of C viruses and the biological consequences of this diversity is important for the design of effective control strategies. We analyzed the protease gene, the first 935 nucleotides of reverse transcriptase, and the C2V5 envelope region of a representative set of 72 treatment-naive patients from KwaZulu-Natal and correlated the results with amino acid signature and resistance patterns."
"Phylogenetic analysis revealed multiple clusters or 'lineages' of HIV-1 subtype C that segregated with other C viruses from southern Africa," reported M. Gordon and collaborators at the University of Natal and the University of Stellenbosch. "The same pattern was observed for both black and Indian subgroups and for retrospective specimens collected prior to 1990, indicating that multiple sublineages of HIV-1 C have been present in KwaZulu-Natal since the early stages of the epidemic. With the exception of three nonnucleoside reverse transcriptase inhibitor mutations, no primary resistance mutations were identified."
"Numerous accessory polymorphisms were present in the protease, but none were located at drug-binding or active sites of the enzyme," said the investigators. ...
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Source: HighBeam Research, Molecular characteristics of HIV-1 subtype C viruses elucidated.