AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Live-attenuated SIV expressing interleukin-4 stimulate immune response.
2003 APR 2 - (NewsRx.com & NewsRx.net) -- Live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma stimulated an immune response in macaques.
According to recent research from Germany, "Nef deletion mutants of SIV-expressing interleukin-4 (SIV-IL4) or interferon-gamma (SIV-IFN) were constructed to study the effect of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) on viral load, immunogenicity, and protective properties. Four rhesus monkeys were infected with SIV-IL4 and four were infected with SIV-IFN. During the acute phase of infection, the cell-associated viral load, but not the plasma viral RNA load, was approximately 10-fold lower in SIV-IFN-infected macaques than in SIV-IL4-infected rhesus monkeys."
"The viral load declined to hardly detectable levels 4 months postinfection in all animals," said Christiane Stahl-Hennig and collaborators at Ruhr-University Bochum, Universitat Erlangen-Nuernberg, and the Deutsches Primatenzentrum. "SIV antibody titers and the affinity of these antibodies were higher in SIV-IL4-infected macaques than in SIV-IFN-infected animals, consistent with a stimulation of T helper cell type 2 immune responses by IL-4. At peak viremia, there was a trend to higher interleukin-12 and perforin mRNA levels of the lymph nodes in the SIV-IFN-infected macaques than in the SIV-IL4-infected monkeys. Deletion of the viral IFN gene, but not the viral IL-4 gene, after the development of antiviral immune responses suggests a repressive ...
- Live-attenuated SIV expressing interleukin-4 stimulate immune response.(simian...
- Newspaper article from: AIDS Weekly March 31, 2003 700+ words
...SIV-IL4) or interferon-gamma (SIV-IFN) were constructed to study the effect...IL4 and four were infected with SIV-IFN. During the acute phase of infection...approximately 10-fold lower in SIV-IFN-infected macaques than in SIV...
- Plasmacytoid dendritic cell activation augments SIV-specific T cells.
- Newspaper article from: Biotech Week October 6, 2004 700+ words
...aldrithiol-2-inactivated (AT-2) SIV induced considerable PDC activation and IFN-a release without needing exogenous...immunostimulatory activity, increasing SIV-specific T cell IFN-gamma production induced by AT-2 SIV-presenting MDC/PDC-enriched...
- Seventeen SIV-derived CD8+ T cell Mamu-A*02-restricted epitopes identified.
- Newspaper article from: AIDS Weekly December 13, 2004 700+ words
...antigenicity of these 75 peptides using an IFN-gamma ELISPOT assay with freshly...PBMC from eight Mamu-A*02+ SIV-infected macaques and identified...discrepancy between tetramer binding and IFN-gamma secretion by SIV-specific CD8+ T cells during...
- Vaccine partial control of SIV replication causes loss of CD4+ T cells.
- Newspaper article from: Drug Week September 24, 2004 700+ words
...with loss of SIV-specific CD4+ T cells in the chronic phase of SIV infection. Thus, SIV-specific CD4+ T cells that were able to produce IFN-gamma in response to SIV antigens were preserved by the vaccine-based partial control of primary...
- Vaccinia virus DIs expressing SIV gag controls SHIV in monkeys.
- Newspaper article from: Drug Week February 6, 2004 700+ words
...simian immunodeficiency virus (SIV). Intravenous inoculation...levels of gamma interferon (IFN-gamma) spot-forming cells (SFC) specific for SIV Gag," scientists in Japan...associated with the peak of IFN-gamma SFC activity in each...
- Retroviral vectors used to analyze SIV/HIV-specific T cell responses.
- Newspaper article from: Health & Medicine Week November 29, 2004 700+ words
...expressing the fall-length SIV-Gag or HIV-Env proteins were...responses, as measured by both IFN-gamma/ELISPOT and chromium...retroviral vector expressing the SIV-Gag protein was more efficient...populations specifically produced IFN-gamma, but only the CD8...
- Vaccine provides T-cell-mediated protection in monkeys after SIV challenge.
- Newspaper article from: Health & Medicine Week December 6, 2004 700+ words
...recombinant viral vectors expressed SIV proteins (Gag, Pol, Tat...immunization while interferon (IFN)-gamma enzyme-linked...challenge with pathogenic SIV[subscript]mac251, three...be the anamnestic T-cell IFN-gamma ELISPOT responses...
- Siv, Sichan: Golden Bones: An Extraordinary Journey from Hell in Cambodia to a...
- Magazine article from: Asian Affairs: An American Review Chai, May-Lee June 22, 2009 700+ words
Siv, Sichan Golden Bones: An Extraordinary Journey...34068-0 Publication Date: July 2008 Sichan Siv's memoir is being marketed as a traditional...immigrant story, celebrating the opportunity Siv found in the United States after fleeing the...
