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Cancer treated using vaccines in mixed allogeneic bone marrow chimeras.
2003 APR 2 - (NewsRx.com & NewsRx.net) -- Successful therapy of metastatic cancer was achieved using tumor vaccines in mixed allogeneic bone marrow chimeras.
According to a study from the United States, "A frequent outcome of allogeneic stem cell transplantation (alloSCT) in the treatment of leukemia is the destruction of the host hematolymphoid compartment and, thus, the malignancy, through the combined action of high-dose chemoradiotherapy and a T-cell-mediated graft-versus-host effect. Unfortunately, alloSCT is frequently limited by toxicity, including graft-versus-host disease (GVHD), and has not been successful in the treatment of tumors derived from solid organs. Here we report a novel cooperation between host and donor T cells in the response to a tumor cell vaccine given after a nonmy-eloablative allogeneic stem cell transplantation (NST) protocol that achieves stable mixed bone marrow chimerism."
"Treatment of animals with NST, post-transplantation donor lymphocyte infusions (DLIs), and a vaccine, comprising irradiated autologous tumor cells mixed with a granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing bystander line, results in potent and specific antitumor immunity," reported Leo Luznik and collaborators at The Johns Hopkins University. "This combined modality immunotherapy, administered after surgical removal of the primary tumor, cured metastatic mammary ...
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Source: HighBeam Research, Cancer treated using vaccines in mixed allogeneic bone marrow...